Journal article
Higher CPAP levels improve functional residual capacity at birth in preterm rabbits
T Martherus, MK Croughan, KJ Crossley, MJ Wallace, EV McGillick, M Thio, CC Roehr, JT Pearson, K Lee, G Ruben, MJ Kitchen, AB te Pas, SB Hooper
Pediatric Research | SPRINGERNATURE | Published : 2022
Abstract
Background: Preterm infants are commonly supported with 4–8 cm H2O continuous positive airway pressures (CPAP), although higher CPAP levels may improve functional residual capacity (FRC). Methods: Preterm rabbits delivered at 29/32 days (~26–28 weeks human) gestation received 0, 5, 8, 12, 15 cm H2O of CPAP or variable CPAP of 15 to 5 or 15 to 8 cm H2O (decreasing ~2 cm H2O/min) for up to 10 min after birth. Results: FRC was lower in the 0 (6.8 (1.0–11.2) mL/kg) and 5 (10.1 (1.1–16.8) mL/kg) compared to the 15 (18.8 (10.9–22.4) mL/kg) cm H2O groups (p = 0.003). Fewer kittens achieved FRC > 15 mL/kg in the 0 (20%), compared to 8 (36%), 12 (60%) and 15 (73%) cm H2O groups (p = 0.008). While bre..
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Awarded by State Government of Victoria
Funding Acknowledgements
The authors thank the support provided by the SPring-8 Japan Synchrotron Radiation Research Institute, which was provided by the SPring-8 Program Review Committee (2016A0132), and gratefully acknowledge the expert assistance of Kentaro Uesugi, Naoto Yagi, Masato Hoshino and Hiroyuki Iwamoto for assistance to conduct our experiments at SPring-8. This experiment was supported by the National Health and Medical Research Council (NHMRC) Program Grant (606789), NHMRC Research Fellowships (SH: APP1058537) and the Victorian Government's Operational Infrastructure Support Program. A.B.t.P. is recipient of an NWO innovational research incentives scheme (VIDI 91716428). E.V.M. was supported by a Monash University Postdoctoral Fellowship (BPF17-0066) and a NHMRC Peter Doherty Biomedical Early Career Fellowship (APP1138049). M.J.K. is a recipient of ARC Future Fellowship (FT160100454). We acknowledge travel funding provided by the International Synchrotron Access Program (ISAP) managed by the Australian Synchrotron and funded by the Australian Government (AS/IA173/12909 and ISP12221).